More than 100,000 people have died of Covid-19 in the US since January 1, JHU data shows

More than 100,000 people have died of Covid-19 in the United States so far this year, according to Johns Hopkins University data.

Since January 1, the US reported a total of 100,317 Covid-19 deaths, bringing the total number of reported deaths in the US since the start of the pandemic to 446,689 by Tuesday evening.

SEATTLE, WA - JANUARY 29: People wait in line for a last-minute COVID-19 vaccine event at Seattle University after a freezer failure at a nearby hospital on January 29, 2021 in Seattle, Washington. The impromptu overnight event was one of three in the city, organized late at night at two University of Washington vaccine clinics and one Swedish Health Services vaccine clinic, to ensure COVID-19 vaccine doses from an area hospital did not go to waste. (Photo by David Ryder/Getty Images)

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The first Covid-19 related death came on February 29, 2020, in Washington state. Later in the spring, two earlier deaths in California were posthumously confirmed to be of Covid-19.

The US has had more Covid-19 deaths than any other country, JHU data shows. Brazil has tallied over 200,000 deaths. Mexico, India and the United Kingdom have all reported over 100,000 deaths.

There are now more vaccinations than reported cases

The number of people who have received at least one dose of the Covid-19 vaccine is now greater thanthe number of US Covid-19 cases reported during the entire pandemic.

More than 26.3 million cases have been reported over the past year, according to Johns Hopkins University.

And in less than two months, more than 26.4 million doses of vaccine have been administered, according to the Centers for Disease Control and Prevention.

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But that doesn’t mean the pandemic is going away. Here’s why:

As part of the Federal Retail Pharmacy Program, chains CVS and Walgreens will begin administering vaccines starting next week. The White House listed 21 national pharmacy chains that will participate in the initial phase of the program.

While CVS and Walgreens have been administered vaccines in some states using those states’ supplies, this is the first time CVS and Walgreens will be sent the vaccine directly from the federal government.

‘This doesn’t appear to be great news for vaccine efficacy’

While viruses mutate all the time, a few variants in particular are worrying scientists:

A patient receives an injection of the Oxford/AstraZeneca Covid-19 vaccine at the vaccination centre set up inside Brighton Centre in Brighton, southern England, on January 26, 2021. - Over 30 new coronavirus vaccination centres were set to open around England this week as Britain's largest ever innoculation programme continued to gain pace. (Photo by Ben STANSALL / AFP) (Photo by BEN STANSALL/AFP via Getty Images)

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– The B.1.1.7 strain first identified in the UK, which might be up to 70% more transmissible than others

– The B.1.351 strain first identified in South Africa, which may reduce vaccine efficacy somewhat

– The P.1 strain first detected in Brazil, which is suspected of fueling a Covid-19 resurgence in that country

All three of those variants have been found in the US, and the B.1.1.7 strain has been detected in at least 32 states.

Johnson & Johnson’s chief scientific officer Dr. Paul Stoffels told CNN’s Richard Quest on Tuesday that the world needs to vaccinate as many people as possible to limit the number of coronavirus variants.

“If we don’t get the pandemic under control soon, then variants will start emerging, and will continue to emerge, and that will result in more vaccinations annually,” Stoffels said. “The mission is to get the virus under control so that it can’t mutate, and it can’t grow and create new versions.”

The Johnson & Johnson vaccine is not yet authorized, but the company said it will ask the US Food and Drug Administration for emergency use authorization this month.

Scientists have now discovered a mutation in at least 11 samples of the B.1.1.7 strain that might escape antibody protection, according to a report Monday by Public Health England.

The mutation, called E484K, was already part of the genetic signature of variants linked to South Africa and Brazil.

WASHINGTON, DC - JULY 2: A model of COVID-19, known as coronavirus, is seen ahead of testimony from Dr. Francis Collins, Director of the National Institutes of Health (NIH), during a US Senate Appropriations subcommittee hearing on the plan to research, manufacture and distribute a coronavirus vaccine, known as Operation Warp Speed, July 2, 2020 on Capitol Hill in Washington, DC. (Photo by Saul Loeb-Pool/Getty Images)

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A new lab study found that antibodies from vaccinated people were less effective at neutralizing a synthetic virus resembling samples of B.1.1.7 that had developed an E484K mutation.

“This doesn’t appear to be great news for vaccine efficacy,” said Joseph Fauver, an associate research scientist in epidemiology at the Yale School of Public Health.

Experts say this news could mean the B.1.1.7 strain, already known to be more transmissible, might be somewhat resistant to the protection given by vaccines, or more likely to cause reinfection among people who were previously infected.

Previous studies suggest that E484K may be the key reason why certain vaccines appear less effective in South Africa. Lab research has also shown that antibodies appear less able to bind and neutralize spike proteins arising from the mutation.

Similarly, Dr. Anthony Fauci told MSNBC’s Chris Hayes on Tuesday that officials have to keep an eye on the variants as they could become a problem if they become dominant.

“One of the wildcards Chris, that we have to keep an eye on, are the mutations, the mutants that are out there, because if they become dominant that then can lead to another surge, but the best way to prevent them from becoming dominant is double-down on public health measures,” Fauci said.

However, Fauci said that “if” Americans double down on public health measures and continue vaccinating, the country should continue to see a downward trend.

Ex-FDA scientist: Stop using convalescent plasma for Covid-19

The US should stop using convalescent plasma to treat the coronavirus because it might help the virus evolve into new and potentially more dangerous variants, a former pandemic adviser to the Biden transition team said.

Convalescent plasma – taken from the blood of Covid-19 survivors – simply does not work well, and allows the virus to keep on replicating and evolving in the bodies of patients, said Dr. Luciana Borio, a longtime biodefense consultant to US administrations.

SEATTLE, WA - APRIL 17: Phlebotomist Jenee Wilson carries COVID-19 convalescent plasma from a donor at Bloodworks Northwest on April 17, 2020 in Seattle, Washington. The plasma will be used in a new experimental treatment in hopes that the antibodies will help others still battling the COVID-19 disease. The plasma donation process, called plasmapheresis, separates blood plasma, from red and white blood cells and platelets, and returns the cells and platelets back to the donor. (Photo by Karen Ducey/Getty Images)

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“As an additional measure to reduce the chances that the virus develops more mutations that could evade the immune system, I would encourage the U.S. Food and Drug Administration to rescind the Emergency Use Authorization (EUA) it issued last year for convalescent plasma,” Borio said in written testimony submitted to the House Energy and Commerce Committee ahead of a Wednesday hearing.

Last August, the FDA issued an emergency use authorization for convalescent plasma to treat Covid-19, saying the “known and potential benefits of the product outweigh the known and potential risks of the product.”

“We already know that, in aggregate, this therapy does not help patients with COVID-19. But by using it in circumstances where it does not work, we are providing the virus with a roadmap that could help it develop mutations that evade natural and vaccine induced immune responses even more rapidly,” wrote Borio, who is currently vice president at strategic investment firm In-Q-Tel.

“Convalescent plasma has been used in more than 150,000 patients despite recommendations by the NIH (National Institutes of Health) that its use should be limited to randomized controlled trials, and now the possibility that its indiscriminate use could add more selective pressure on the virus and hasten the day when vaccines become less effective,” said Borio, who is also a former acting chief scientist for the FDA.

Pfizer to deliver 200 million vaccine doses 2 months earlier than planned

The maker of one of two vaccines currently administered in the US confirmed Tuesday that it expects to deliver 200 million doses to the US by the end of May.

Pfizer was originally scheduled to deliver the 200 million doses by July 31. But CEO Albert Bourla said last week he expects the company’s production to be ahead of schedule by two months.

Pharmacist Jason Hyde fills syringes with the Moderna Covid-19 vaccine as first responders wait to receive it at UMass Memorial Hospital in Marlborough, Massachusetts on January 12, 2021. - First Responders started to receive their vaccinations on January 11, as part of the phase one of vaccinations roll out in Massachusetts. (Photo by Joseph Prezioso / AFP) (Photo by JOSEPH PREZIOSO/AFP via Getty Images)

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“In the US, we had promised to provide 100 million doses by the end of the first quarter and we will be able to provide 120 right now,” Bourla said last week.

“The same is with second quarter. We were planning to provide them all the way to 200 million doses by the end of the second quarter, actually beginning of the third. Right now, we will be able to provide the 200 million doses two months earlier.”

The Biden administration has announced it will be purchasing an additional 100 million doses from the company.

Pfizer said it had supplied 20 million doses to the US as of Sunday.

Both Pfizer’s vaccine and the vaccine made by Moderna require two doses, spaced 21 days and 28 days apart.

CNN’s Kevin Liptak, Sara Murray, Betsy Klein, Virginia Langmaid, Michael Nedelman, Amanda Sealy, Nina Avramova, Maggie Fox, John Bonifield, Amanda Watts, Andrea Diaz, Deidre McPhillips, Gisela Crespo and Laurie Ure contributed to this report